Unique Nanoparticle Characterization: The NanoFlowSizer
The ONLY TRUE inline Nanoparticle Analyzer in the Market today
The need for inline nanoparticle sizing
The use of nanoparticles has become increasingly popular in multiple industries, such as pharma, chemicals, cosmetics, and food & dairy.
Nanotechnology in healthcare has an exceptional potential to address a diversity of therapeutic issues by providing better diagnostics and therapy. A broad range of nanoparticle enabled products are available for pharmaceutical medical applications (drug delivery), including liposomes, polymeric nanoparticles and lipid-based nanoparticles.
Unique benefits of SR-DLS
- Analysis of highly turbid suspensions
- Measurement in flow
- Sample preparation not necessary
- Real-time process control
- Monitoring of continuous manufacturing possible
Learn more about SR-DLS
Limitations of conventional technologies…
- Low control during the production process
- Interruption of the manufacturing process flow at quality control stage
- Need for off-line laboratory analysis, could result in potential delays
- Impossible to carry out realtime control of nanoparticle size during continuous manufacturing
- Batch to batch quality might vary
- Delayed process quality feedback, due to long analysis time
A unique nanoparticle sizer: the NanoFlowSizer
The importance of particle size analysis
In pharmaceutical products, the size and size distribution of nanoparticles directly affects the efficacy and safety of nanomedicines for patients. For specialty chemicals, where nanosuspension are abundant in (intermediate) products such as diverse coating, inks, paints and ceramics, the suspension performance is also critically related to the particle size distribution.
Uncompromised monitoring
Pharma industry demands complete control over manufacturing processes, following Quality by Design principles compliant with stringent regulatory requirements. Therefore sophisticated, highly efficient Process Analytic Technology (PAT) is required. The historical lack of PAT for particle size characterization in the nanomedicine development and manufacturing is uniquely solved by the SR-DLS technology of the NanoFlowSizer.
Nanoparticles and their applications
Nanoparticles could be natural or synthetic particles by nature with a size 1-1,000 nm. Due to their ultra-small size they have a large surface area in relation to their volume, providing them with special properties.
Nanoparticles are present in many of the items in our everyday life, such as sunscreens, medicines, inks etc.. Of special interest within the pharmaceutical industry, nanoparticles could be used in different formulations, such as drug delivery systems for transporting systems through the body.
The InProcess-LSP solution
The NanoFlowSizer
- Reduction in analysis time, results in seconds
- Increased process understanding
- Particle size information in real time
- Reduction of production time
- Potential for significant batch reductions
Why is the NanoFlowSizer different?
The NanoFlowSizer (NFS) is a nanoparticle size analyzer that can measure nano dispersions over unprecedented turbidity levels, inline or online in process flows from <<ml/min to >100L/hr, and at/off-line in any transparent container. These unique features result from the instruments ‘Spatially Resolved’ Dynamic Light Scattering technology, giving >1000 simultaneous DLS measurements at different depth in the sample.
Results every 10 sec
With the NanoFlowSizer, nanoparticle size measurement takes place in less than 10s, enabling continuous real-time monitoring.
How do I compare different DLS instruments?
Dynamic Light Scattering is used to measure the hydrodynamic size and size dispersity of nanoparticles in suspension. The configuration of a DLS instrument can affect the measured particle size.
We explain how results from DLS instruments operating at different wavelengths and scattering angles are related using practical examples and light scattering theory.
We are extremely impressed by the system and the quality of the data!
Top 5 vaccine manufacturer
Process monitoring
Poor process control can result in uncertain product quality, leading to high rejection rates in batch production for (pharmaceutical) products.
The inline functionality of the NanoFlowSizer allows complete control over the production process. This is highly advantageous for quality demands in pharmaceutical manufacturing.
Save unnecessary costs
Avoiding offline laboratory analysis and having full control over particle size related quality of your product during manufacturing prevent delays or batch rejection during manufacturing. As a result, the NanoFlowSizer can provide major annual savings.
“As an inline instrument, the NanoFlowSizer is a powerful non-invasive Process Analytical Tool allowing close monitoring of particle size characteristics in your process.”
Average particle size and size distributions in seconds
- Continuous size characterization of nanoparticles during processing
- Inline Process Analytical Tool
- Non-invasive measurement
- Real-time process feedback
- Measurement of highly turbid materials
- High-speed measurement
- Inline, online and offline operation
- For very small (<<mL) to large sample volumes
Up to millions is lost per year due to the absence of appropriate
particle size monitoring solutions…
What can the NanoFlowSizer mean for your process?
Excellent quality control
Measuring particle size and distribution in real time allows process engineers to correct processing conditions or even automated process control.
Outcome: prevent batch rejection. .
Full non-invasive measurement
The NanoFlowSizeris suitable for virtually any process connection or sample container to measure turbid solutions eliminating sample manipulation. This provides higher measurement efficiency and full compatibility with sterile manufacturing.
Outcome: efficient PAT providing safe products..
Real-time measurement
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Direct real time process insight promotes understanding and efficiency both in product and process development and during manufacturing.
Outcome: efficient R&D and Process Improvement..
Timely Analysis
The NanoFlowSizer offers significantly faster analysis time and no sample preparation time. Particle size data is measured in less than 10 sec.
Outcome: significant reduction of total analysis time.
Outcome: Faster infirmation about product quality.