The ONLY TRUE inline nanoparticle analyzer in the market today
The need for inline nanoparticle sizing
The use of nanoparticles has become increasingly popular in multiple industries, such as pharma, chemicals, cosmetics, and food & dairy.
Nanotechnology in healthcare has an exceptional potential to address a diversity of therapeutic issues by providing better diagnostics and therapy. A broad range of nanoparticle enabled products are available for pharmaceutical medical applications (drug delivery), including liposomes, polymeric nanoparticles and lipid-based nanoparticles.
- Analysis of highly turbid suspensions
- Measurement in flow
- Sample preparation not necessary
- Real-time process control
- Monitoring of continuous manufacturing possible
This leads to:
Higher efficiency manufacturing and economic benefits!
Limitations of conventional technologies…
- Low control during the production process
- Interruption of the manufacturing process flow at quality control stage
- Need for off-line laboratory analysis, could result in potential delays
- Impossible to carry out realtime control of nanoparticle size during continuous manufacturing
- Batch to batch quality might vary
- Delayed process quality feedback, due to long analysis time
A unique nanoparticle sizer: the NanoFlowSizer
The importance of particle size analysis
Particle size and Particle size distribution of nanoparticles could directly affect effacicy and savety for patients in pharam applications.
Since the behavior of particles at nanoscale depends highly on these properties, control of nanoparticle size is paramount from development up to manufacturing.
Pharma industry demands complete control over manufacturing processesthat need to comply with stringent regulations and demands. As a result sophistated, highly efficient Process Analytic Technologies (PAT) might be required.
However, there is currently a lack of suitable PAT solutions for monitoring nanoparticle size and particle size distribution.
Nanoparticles and their applications
Nanoparticles could be natural or synthetic particles by nature with a size 1-1,000 nm. Due to their ultra small size they have a large surface area in relation to their volume, providing them with special properties.
Nanoparticles are present in many of the items in our everyday life, such as sunscreens, medicines, inks etc.. Of special interest within pharmaceutical idustry, nanoparticles could be used in different formulations, such drug delivery systems for transporting systems through the body.
The InProcess-LSP solution
- Reduction in analysis time, results in seconds
- Increased process understanding
- Particle size information in real time
- Reduction of production time
- Potential for significant batch reductions
Why is the NanoFlowSizer different?
The NanoFlowSizer (NFS) is a new non-invasive nanoparticle size analyzer developed by InProcess-LSP. This technology is the only one capable of analyzing particle size and size distribution measurements for liquid materials. This can be done inline at production flow with no need to dilute or treat sample material.
Results every 10 sec
With the NanoFlowSizer, nanoparticle size measurement takes place in less than 10s, enabling continuous real-time monitoring.
We are extremely impressed by the system and the quality of the data!
Top 5 vaccine manufacturer
Poor process control could result in uncertain product quality, leading to high rejection rates in batch production for (pharmaceutical) products.
The inline functionality of the NanoFlowSizer allows complete control over the production process. This could be an advantage for high-quality demands in pharmaceutical manufacturing.
Save unnecessary costs
Having full control over the quality of your product during manufacturing could lead to a reduction of batch rejection related to nanoparticle size. This reduces the need for offline laboratory analysis, preventing delays during manufacturing. As a result, the NanoFlowSizer can provide major annual savings.
“As an inline instrument, the NanoFlowSizer is a powerful non-invasive Process Analytical Tool allowing close monitoring of particle size characteristics in your process.”
Average particle size and size distributions in seconds
- Continuous size characterization of nanoparticles during processing
- Inline Process Analytical Tool
- Non-invasive measurement
- Real-time process feedback
- Measurement of highly turbid materials
- High-speed measurement
- Inline, online and offline operation
- For very small (<<mL) to large sample volumes
Up to millions is lost per year due to the absence of appropriate
particle size monitoring solutions…
What can the NanoFlowSizer mean for your process?
Excellent quality control
Measuring particle size and distribution in real time allows process engineers to correct processing conditions. Outcome: No discard of batches after production..
The NanoFlowSizer offers significantly faster analysis time and no sample preparation time. Particle size data is measured in less than 10 sec. Outcome: significant reduction of total analysis time.
The device measures non-invasively concentrated turbid solutions eliminating the need to extract & dilute samples. This allows sterile manufacturing. Outcome: Safe products.
Greater process insight and control in real time promotes efficiency as process engineers have a better understanding and control over manufacturing dynamics. Outcome: Faster infirmation about product quality.
Benefits for you
- Insight in process dynamics
- Cost reduction
- Faster processing
- Less waste
- Reduced process steps
- Continuous improvement