Launching in 2026 – unique solution:

Real-time
transfection complex size monitoring

Non-invasive, real-time particle size during complex formation — in closed vials, flasks, and bags.

Transient transfection complex size monitoring

Why it matters

The size of the transfection complex has a major impact on transfection performance – too small or too large can quickly reduce yield.

Because the optimal range can be narrow, even small changes during complex formation can introduce variability — leading to repeated experiments, longer development cycles, and higher cost.

By monitoring complex size during formation, you can more consistently reproduce the mixing conditions that generate the size range you’re targeting — improving consistency and reducing development time.

You would like:

To increase yield,
reduce variability,
and cut development time
by keeping complex size in the optimal range.

Customer insight

“Variability in complex size and lack of direct size information results in suboptimal yields and significant costs.”
MeiraGTX, Sartorius

The NanoLabSizer

What can you expect?

Real-time size measurements during complex formation
Maintains sterility
Direct non-invasive measurements in closed vials, tubes, flasks or bags (up to 3L)
Continuous measurements (every 10-20s) covering full dynamic picture
Monitors the relation between complex size and transfection efficiency
Ideal system for upstream process development and validation

NanoLabSizer: Real-Time Visibility, Zero Interruption

How can you improve your PEI-based transient transfection process?

Transfection is a powerful production step—but small changes during complex formation can create big differences in performance, time, and cost, which is why the field is moving from trial-and-error to data-driven control.

In this article, you’ll learn why particle/complex size is a major driver that links upstream preparation to efficiency, yield, and reproducibility.

You’ll also see how non-invasive, real-time size monitoring during mixing helps pinpoint the optimal moment—without sampling delays or disrupting sterility.

Download the article to explore practical benefits like fewer experiments, less hands-on work, and a more accurate “recipe” that can lift titre/yield by 15–30%.