THALIA

For high sensitivity

3 – 5000 nm
High sensitivity in low concentrations
Data every 5 seconds
Aggregation monitoring
Real-Time and non-invasive
Powerful PAT tool

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Free THALIA information

NanoFlowSizer THALIA

Your solution for

Protein analysis for ADC, mAb, pAb, viruses
Sample stability screening
Aggregation monitoring
Large Particle Detection
Inline Design of Experiments: formulation screening

THALIA – High-Sensitivity Nanoparticle Size Analysis

THALIA is a cutting-edge particle size analyzer designed for highly sensitive measurements in low concentrations. It provides real-time, continuous monitoring of proteins, monoclonal antibodies (mAbs), and other biologics, making it ideal for stability screening and aggregation monitoring. With its non-invasive measurement technology, THALIA ensures precise insights into nanoparticle behavior without sample dilution or preparation. Fully customizable for lab, pilot, and production scales, and powered by GMP-compliant XsperGo software, it supports efficient formulation development and process optimization while reducing batch failures and operational costs.

Unique Features & Benefits

Measure non-invasive in any transparent container
Continuous data collection in real-time (<5sec)
Particle size & size distribution
Hydrodynamic diameter, PDI, D90
Modules available for lab, pilot and manufacturing scale
XsperGo software is GMP-compliant and OPC-UA compatible
Cost-effective real-time monitoring reducing operational costs
Reduced risk of batch failures
Automatic process feedback

“The NanoFlowSizer proves to be a valuable PAT tool”

thalia-nanoparticle-measurement-instrument

Hardware solutions

Customized system configuration for small, medium, large scale flow- and offline analysis
Trolley-mounted systems

Software solutions

PhaSR: your solution for very low particle size & low concentrations
Large Particle Detection (LPD): extra imaging feature

“Accurate particle sizing is key for nanomedicine;
the NanoFlowSizer makes it a real-time reality”

Specifications

System feature	THALIA
Measurement principle:	Spatially Resolved Dynamic Light Scattering (SR-DLS)
Particle Size Range:	3 nm – 5000 nm
Measurement angle:	180° backscatter
Measuring mode:	flow & static
Configuration:	inline, online, at-line, offline
Data collection:	real-time/continuous <5 sec per datapoint
Flow rate:	<250 L/hr
Wavelength:	1250 to 1350 nm
Turbidity*:	low to very high
Sample size:	>1 ml