Fides
For wide turbidity ranges
- 15 – 5000 nm particle size range
- Hydrodynamic diameter, PDI, D90
- Data every 5 seconds
- Real-time and non-invasive
- Measure non-invasive in any transparent container
NanoFlowSizer FIDES
Your solution for
- Lipid-NanoParticle manufacturing
- Active Pharmaceutical Ingredient Milling
- Crystallization & Polymerization
- Emulsification & HPH process monitoring
- Large Particle Detection
- Aggregation monitoring
FIDES – Real-time Nanoparticle Size Analysis
FIDES is an advanced particle size analyzer designed for real-time monitoring in highly turbid samples. Using innovative technology, it enables continuous, non-invasive measurement of nanoparticles in various processes, including LNP manufacturing, emulsification, and crystallization. With its flexible integration across lab, pilot, and production scales, FIDES helps optimize process efficiency, reduce batch failures, and lower operational costs. Its GMP-compliant software and customizable solutions make it a powerful PAT tool for pharmaceutical and industrial applications.
Unique Features & Benefits
- Continuous data collection in real-time (<5sec)
- Particle size & size distribution
- Fully customizable to specific process
- Modules available for lab, pilot and manufacturing scale
- XsperGo software is GMP compliant and OPC-UA compatible
- Cost-effective real-time monitoring reducing operational costs
- Reduced risk of batch failures
- Automatic process feedback
- Powerful PAT tool
“Ideal for inline analysis of lipid nanoparticles”
Software solutions
- PhaSR DLS: your solution for very low particle size & low concentrations
- Large Particle Detection (LPD): extra imaging feature
Hardware solutions
- Customized system configuration for small, medium, large scale flow- and offline analysis
- Online Micro Dilution (OMD): your solution for extremely high turbidities and concentrations
- Trolley-mounted systems
“Integrating the NanoFlowSizer FIDES has significantly reduced batch failures in our vaccine production through precise inline monitoring”
Specifications
| System feature | FIDES |
|---|---|
| Measurement principle: | Spatially Resolved Dynamic Light Scattering (SR-DLS) |
| Particle Size Range: | 15 nm – 5000 nm |
| Measurement angle: | 180° backscatter |
| Measuring mode: | flow & static |
| Configuration: | inline, online, at-line, offline |
| Data collection: | real-time/continuous <5 sec per datapoint |
| Flow rate: | <250 L/hr |
| Wavelength: | 1200 to 1400 nm |
| Turbidity*: | low to very high |
| Sample size: | >1 ml |
*Turbidity ranges are particle type and solvent dependent and must be experimentally determined.
Highly turbid samples
No dilution necessary
- SR-DLS allows for nanoparticle analysis in highly turbid suspensions
- No sample pretreatment necessary
- Find out more about the SR-DLS technology…
Related Applications
Related documents
Accessories & Software
Flowcells
Various replaceable sample modules are available to equip the NanoFlowSizer with an optimal interface to your sample or process.
XsperGo
The XsperGo software supports the operation of the NanoFlowSizer and unravels large amounts of data into meaningful particle size information.
Trolley Solutions
Enhance mobility and efficiency with our specially designed trolleys, we offer two optimized trolley versions to meet different application needs.