Fides
Real-Time
Nanoparticle Size Analysis for
Process Development
- Suitable for low to very high turbidity samples
- Real-time particle size data in seconds
- Inline, online, at-line, or offline configuration
- Designed for lab, pilot, and manufacturing scale
- Modular flexibility
What is the NanoFlowSizer FIDES?
The FIDES is a NanoFlowSizer system for continuous nanoparticle size analysis under process-relevant conditions. Using Spatially Resolved Dynamic Light Scattering (SR-DLS), it provides real-time particle size and distribution data without the delays of conventional offline workflows. It is especially suited to applications where turbidity is high, process conditions are demanding, and fast feedback is valuable for development, optimization, and manufacturing.
Key considerations in process nanoparticle size analysis
In development and manufacturing, obtaining representative particle size data is not always straightforward. Samples may be highly turbid, process conditions can change quickly, and delayed offline measurements may not reflect what is happening in the process when decisions need to be made. FIDES is designed for these environments, where speed, robustness, and non-invasive measurement are especially important.
High turbidity can limit analysis
Very concentrated and turbid samples can be challenging for conventional methods.
Offline measurements delay decisions
Manual sampling and preparation can slow feedback and delay process adjustments.
Representative process data is hard to obtain
Measurements taken outside the process may not fully reflect actual operating conditions.
Some processes require extra flexibility
Very high turbidity or smaller particles may require additional measurement options.
Why choose the NanoFlowSizer FIDES?
The FIDES is designed for applications requiring robust, real-time particle-size analysis across a broad turbidity range. It supports both development and manufacturing workflows and can be configured for inline, online, at-line, or offline use.
For those working with concentrated formulations, fast-changing processes, or scale-up environments, the FIDES provides a more representative alternative to conventional lab-only workflows.
Key benefits
- Real-time particle size feedback
- Suitable for low to very high turbidity samples
- Non-invasive measurement under process-relevant conditions
- Flexible configuration from lab to manufacturing scale
- GMP-compliant and OPC-UA-compatible software environment
- Optional modules for extremely high turbidity, larger particles, and extended measurement needs
- Supports faster process understanding and reduced operational risk
Typical application areas
- Lipid nanoparticles
Monitor particle size during development and manufacturing of lipid-based nanoparticle systems where real-time insight supports process understanding and control. - API milling
Track particle size changes in milling workflows where timely data can support process optimization and product consistency. - Crystallization and polymerization
Follow particle growth and size evolution in demanding particle formation processes where representative, continuous measurement is valuable. - Emulsification and high-pressure homogenization
Measure particle or droplet size in turbid process streams without relying solely on delayed offline testing. - Aggregation monitoring
Detect size shifts during development or manufacturing to improve visibility into aggregation behavior and process stability. - Aggregation and large particle detection
Add optional Large Particle Detection when insight into larger particles is important alongside nanoparticle size analysis.
Highly turbid samples
Direct measurement without dilution
- Maintains sterility
- No sample pretreatment necessary
- Based on the SR-DLS technology
Optional modules and software
The FIDES can be expanded with additional modules to match more demanding measurement conditions. The Online Micro Dilution (OMD) module supports applications with extremely high turbidity or concentration. Large Particle Detection (LPD) adds imaging-based detection for larger particles. PhaSR extends the platform for very low particle size and low-concentration applications when broader flexibility is needed within the NanoFlowSizer platform. The FIDES is supported by XsperGo software and can be configured for different scales and workflows, including GMP-compliant and OPC-UA-compatible environments.
“Precise inline monitoring helps improve process visibility and reduce the risk of batch failure during production.”
Key specifications
| System feature | FIDES |
|---|---|
| Measurement principle: | Spatially Resolved Dynamic Light Scattering (SR-DLS) |
| Particle Size Range: | 15 nm – 5000 nm |
| Measurement angle: | 180° backscatter |
| Measuring mode: | Flow & static |
| Configuration: | Inline, online, at-line, offline |
| Data collection: | Real-time/continuous <5 sec per datapoint |
| Flow rate: | <250 L/hr |
| Wavelength: | 1200 to 1400 nm |
| Turbidity*: | Low to very high |
| Sample size: | >1 ml |
Need real-time particle size insight in demanding process conditions?
The FIDES supports measuring nanoparticles under process-relevant conditions with fast, non-invasive feedback and broad configuration flexibility. For high-turbidity environments, scale-up workflows, and manufacturing applications, it provides a more representative view of particle size where conventional offline methods can fall short.
“Designed for inline analysis of lipid nanoparticles”