Fides
Advanced Real-Time Nanoparticle Size Analysisβ
- 15 – 5000 nm particle size range
- Hydrodynamic diameter, PDI, D90
- Data every 5 seconds
- Real-time and non-invasive
- Measure non-invasive in any transparent container
Introducing the NanoFlowSizer FIDES instrument
Instrument for high turbidity
The NanoFlowSizer FIDES is a NanoFlowSizer system designed for real-time nanoparticle size analysis in demanding, high-turbidity processes like LNP process development, emulsification, milling, and nanoparticle synthesis.
Based on Spatially Resolved DLS
Using SR-DLS, it delivers continuous size distribution metrics without sampling or dilution, from lab to production scale. The FIDES is ‘the sister platform’ to the NanoFlowSizer THALIA, designed for complementary measurement conditions.
NanoFlowSizer FIDES
Your solution for
- Lipid-NanoParticle manufacturing
- Active Pharmaceutical Ingredient Milling
- Crystallization & Polymerization
- Emulsification & HPH process monitoring
- Large Particle Detection
- Aggregation monitoring
The NanoFlowSizer FIDES β Real-time Nanoparticle Size Analysis
The FIDES uses Spatially Resolved Dynamic Light Scattering (SR-DLS) to deliver continuous nanoparticle size and distribution data in challenging, highly turbid process streams.
It covers a broad particle size range (15β5000 nm) and reports key metrics such as hydrodynamic diameter, PDI and D90, with new results every ~5 seconds. The FIDES can be used in flow or static mode and configured inline, online, at-line or offline, with system modules available for lab, pilot and manufacturing scale.
For demanding conditions, optional solutions such as Online Micro Dilution (OMD) (for extremely high turbidity/concentration), Large Particle Detection (LPD) imaging, and PhaSR (for very low particle size/low concentrations) can be added to match your process needs.
Its GMP-compliant software and customizable solutions make it a powerful PAT tool for pharmaceutical and industrial applications.
Key Features of the NanoFlowSizer FIDES
- Continuous data collection in real-time (<5sec)
- Particle size & size distribution
- Fully customizable to specific process
- Modules available for lab, pilot and manufacturing scale
- XsperGo software is GMP compliant and OPC-UA compatible
- Cost-effective real-time monitoring reducing operational costs
- Reduced risk of batch failures
- Automatic process feedback
- Powerful PAT tool
“Ideal for inline analysis of lipid nanoparticles”
Software solutions
- PhaSR DLS: your solution for very low particle size & low concentrations
- Large Particle Detection (LPD): extra imaging feature
- GMP compliant
Hardware solutions
- Customized system configuration for small, medium, large scale flow- and offline analysis
- Online Micro Dilution (OMD): your solution for extremely high turbidities and concentrations
- Trolley-mounted systems
“Integrating the NanoFlowSizer FIDES has significantly reduced batch failures in our vaccine production through precise inline monitoring”
Specifications
| System feature | FIDES |
|---|---|
| Measurement principle: | Spatially Resolved Dynamic Light Scattering (SR-DLS) |
| Particle Size Range: | 15 nm – 5000 nm |
| Measurement angle: | 180Β° backscatter |
| Measuring mode: | Flow & static |
| Configuration: | Inline, online, at-line, offline |
| Data collection: | Real-time/continuous <5 sec per datapoint |
| Flow rate: | <250 L/hr |
| Wavelength: | 1200 to 1400 nm |
| Turbidity*: | Low to very high |
| Sample size: | >1 ml |
*Turbidity ranges are particle type and solvent dependent and must be experimentally determined.
Highly turbid samples
No dilution necessary
- Maintains sterility
- No sample pretreatment necessary
- Based on the SR-DLS technology
