THALIA
sensitive Nanoparticle Analysis for Biopharmaceutical Applications
- 3 – 5000 nm
- High sensitivity in low concentrations
- Data every 5 seconds
- Aggregation monitoring
- Real-Time and non-invasive
- Powerful PAT tool
Introducing the NanoFlowSizer FIDES instrument
Instrument for high sensitivity
The NanoFlowSizer THALIA is a NanoFlowSizer system designed for high-sensitivity nanoparticle sizing at low concentrations – ideal for biopharmaceutical and protein-based applications. Using SR-DLS, it provides real-time, non-invasive size and aggregation monitoring (e.g., for proteins and monoclonal antibodies) without dilution or extensive sample preparation.
Based on Spatially Resolved DLS
The THALIA is the sister platform to the NanoFlowSizer FIDES, covering complementary conditions when higher turbidity and in-process monitoring are required.
NanoFlowSizer THALIA
Your solution for
- Protein analysis for ADC, mAb, pAb, viruses
- Sample stability screening
- Aggregation monitoring
- Large Particle Detection
- Inline Design of Experiments: formulation screening
THALIA – High-Sensitivity Nanoparticle Size Analysis
The THALIA provides real-time, continuous monitoring of proteins, monoclonal antibodies (mAbs), and other biologics, making it ideal for stability screening and aggregation monitoring. With its non-invasive measurement technology, the THALIA ensures precise insights into nanoparticle behavior without sample dilution or preparation. Fully customizable for lab, pilot, and production scales, and powered by GMP-compliant XsperGo software, it supports efficient formulation development and process optimization while reducing batch failures and operational costs.
Unique Features & Benefits
- Measure non-invasive in any transparent container
- Continuous data collection in real-time (<5sec)
- Particle size & size distribution
- Hydrodynamic diameter, PDI, D90
- Modules available for lab, pilot and manufacturing scale
- XsperGo software is GMP-compliant and OPC-UA compatible
- Cost-effective real-time monitoring reducing operational costs
- Reduced risk of batch failures
- Automatic process feedback
“The NanoFlowSizer proves to be a valuable PAT tool”
Hardware solutions
- Customized system configuration for small, medium, large scale flow- and offline analysis
- Trolley-mounted systems
Software solutions
“Accurate particle sizing is key for nanomedicine;
the NanoFlowSizer makes it a real-time reality”
Specifications
| System feature | THALIA |
|---|---|
| Measurement principle: | Spatially Resolved Dynamic Light Scattering (SR-DLS) |
| Particle Size Range: | 3 nm – 5000 nm |
| Measurement angle: | 180° backscatter |
| Measuring mode: | Flow & static |
| Configuration: | Inline, online, at-line, offline |
| Data collection: | real-time/continuous <5 sec per datapoint |
| Flow rate: | <250 L/hr |
| Wavelength: | 1250 to 1350 nm |
| Turbidity*: | Real-time/continuous <5 sec per datapoint |
| Sample size: | >1 ml |
*Turbidity ranges are particle type and solvent dependent and must be experimentally determined.
