Frequently Asked Questions
NanoFlowSizer – Your Questions, answered.
What can I measure with it?
- Lipid nanoparticles (LNPs)
- Protein complexes & transfection systems
- ADCs and monoclonal antibodies
- API milling, emulsions, crystallization, polymerization
→ Plus: aggregation, stability, and dispersity monitoring
What are typical applications?
- Pharma & biopharma
- LNP-based vaccines
- Protein & ADC therapeutics
- Food, inks, cosmetics, chemicals
If particle size matters to your process, NanoFlowSizer fits.
What size range can it measure?
- From 3 nanometers to 5 micrometers
What makes it different from traditional DLS?
Most DLS systems require:
- Clear, diluted samples
- Offline prep and waiting
NanoFlowSizer measures:
- Directly in flow
- In-line, in real-time
- Without dilution—even in turbid or dense formulations
Can it handle cloudy samples?
- Yes! It’s made for low to high concentrations; and from low to highly turbid formulations.
What if my pump creates pulsations?
- If your process causes strong pulsations, we recommend using dampeners or steady flow setups. The software compensates for flow as much as possible.
Does it account for temperature and solvent effects?
- Yes. The system adjusts automatically for viscosity, refractive index, and temperature. Custom solvents can be uploaded too.
What if my sample contains both small and large particles?
- It depends. If there are a lot of large particles, they can interfere. But if they’re only a small part of the mix, NanoFlowSizer can still track the nanosized ones.
How does it measure?
- Completely non-invasive. Through flow cells, vials, IV-bags, syringes, or other transparent containers—no contact and no need to dilute.
What results do I get?
- Hydrodynamic particle size
- d10, d50, d90
- Polydispersity Index (PDI)
- Full particle size distribution
All refreshed every few seconds.
Good to Know
- No calibration required
- Works from uL to manufacturing scale high volumes
- Connects to SCADA / PAT (OPC-UA)
- Offline data reprocessing included
- Fully GMP & 21 CFR part 11 compliant
- ATEX environments? Custom options available—ask us!
Available Worldwide
Lab testing available.
Rent or lease options.
Friendly support team.
Let’s make real-time analytics part of your workflow.
Interested in discussing sample testing or integration?
Email us at sales@inprocess-lsp.com.
Or contact us here.
“Real-time nanoparticle size analysis.
No dilution. No waiting. Just results.”
The NEXT-level particle analysis technology in LNP continuous processing
Rut Besseling, Science Director at InProcess-LSP