

Smart Bypass Loop
Controlled laminar flow for demanding inline environments
- Designed for challenging in-line process conditions
- Creates a controlled laminar flow loop
- Reduces the impact of pulsation, shear, and air bubbles
Challenges in inline size monitoring
In manufacturing environments, flow conditions can be complex and dynamic. Pulsation, high flow rates, high shear, and entrained air bubbles can interfere with flow correction and reduce the accuracy of inline particle size measurements. In these situations, measurement quality depends not only on the sizing technology itself, but also on how well the sampling conditions can be controlled.
The Smart Bypass Loop is designed to address this challenge by creating a dedicated loop with more stable flow conditions, better suited for accurate size analysis.
In demanding inline processes, unstable flow conditions can interfere with flow correction and reduce measurement accuracy.
As shown in the flow cell schematic, the NanoFlowSizer relies on laminar flow for accurate measurement.
The Smart Bypass Loop is designed to create these controlled flow conditions under challenging inline process conditions.

Flow illustration in the NanoFlowSizer
What is the Smart Bypass Loop?
In addition to standard module features such as integrated temperature sensors, it creates a continuous laminar flow within its own loop. This improves control over fluid conditions and supports more accurate particle size measurements.
Depending on the setup, sampled fluid can be returned to the main stream or diverted to waste, giving flexibility in how the module is integrated into a process line.
Why use the Smart Bypass Loop?
Main components
The Smart Bypass Loop includes the following main components:
- 0.25-inch flow cell module
- Bypass
- Continuous / stop-flow method
- Disposable tubing and pump head
- Smart gasket connections

Designed for controlled sampling in real process environments
The Smart Bypass Loop is built for applications where direct measurement in the main stream may be affected by unstable or less predictable flow behavior. By creating a controlled bypass loop, it helps establish sampling conditions that are better suited for robust and accurate inline particle size analysis.
Feature highlights:
- Operates at flow rates below 45 mL/min
- Creates a continuous laminar flow loop
- Smart gasket technology enables sampling directly from the main stream
- Compact footprint for easier integration
- Easy to operate and easy to clean
All of these features are intended to improve fluid control and simplify use in real process settings.

A NanoFlowSizer accessory for more demanding flow conditions
The NanoFlowSizer platform is designed as a flexible system for particle size analysis in process-relevant environments. Accessories help adapt the setup to different workflows, sample conditions, and integration requirements.
Within this portfolio, the Smart Bypass Loop is intended for processes where improved flow control can strengthen measurement quality and make inline particle sizing more robust.
Want to see whether the Smart Bypass Loop fits your process?
If your process involves pulsation, shear, entrained air, or flow conditions that make direct inline measurement more difficult, the Smart Bypass Loop may help create a better-controlled measurement environment. Talk to our team about the best NanoFlowSizer configuration for your workflow.