Supporting your process with spectroscopy technologies

Blend uniformity


NIR imaging – Powder




Near-Infrared (NIR)

Thanks to major advantages related to the non-destructive character, ability to measure through glass, speed of analysis and versatility of the equipment, NIR is widely used for process analytical applications.

One of the most common challenges for NIR applications is the quantitative calibration and interpretation of NIR spectra and data. InProcess-LSP works with spectroscopy hardware suppliers and offers extensive experience in NIR and chemometric modeling for at-line and on- or inline PAT solutions for solids and suspensions.

Combine NIR with NanoFlowSizer

InProcess-LSP can support you to develop and implement your application by making use of time-efficient and proven testing and calibration protocols.

Besides supporting PAT NIR application development, InProcess-LSP aims to combine spectroscopy solutions with the NanoFlowSizer technology to create ‘multi-PAT’ solutions to extend particle size data with additional information about composition, concentration and other relevant chemical or physical properties. 

Software for specific PAT solutions, commercially available software may not fulfill all requirements for effective operation and data interpretation. InProcess-LSP can support you to develop software and user interfaces for specific application areas. The starting point of InProcess-LSP is the non-exclusivity of developed software in order to keep development costs as low as possible for the customer.

Inline Blend Uniformity

Inline monitoring or control of powder blending processes provides major advantages in terms of process understanding, efficiency, cost-saving and risk reduction in process development, tech transfer and manufacturing.

Proven strategy for high-quality approach

Applying an efficient and proven strategy for development and validation specifically for blend uniformity methods (either at InProcess-LSP or customer site), InProcess-LSP assures a highly efficient and high-quality approach for you as a customer.


NIR Imaging

Imaging analysis by NIR provides valuable information about spatially distributed ingredients. The uniformity of powder blends, tablets or other solid samples can be investigated by hyperspectral NIR images.

Valuable tool for understanding process

For either R&D or routine operation, environment NIR imaging may be a valuable tool for either increased understanding of your process and product, or continuous quality control during production. NIR imaging involves besides processing of NIR spectra also (advanced) imaging analysis in order to extract the desired information from the images.

In the frontline of Process Analytical Technology


Combining spectroscopic methods like NIR with the NanoFlowSizer extends the range of information that can be extracted from the sample.

Besides particle size, additional information about concentration and compositions or other relevant properties may be obtained.

Since the NanoFlowSizer measures non-invasively through glass, combining with other non-invasive technologies like NIR will not jeopardize the non-invasive character of the measurements.

‘Multi-PAT’ is also one of the focus areas of the EU-funded PAT4Nano consortium in which InProcess-LSP is represented as well.

Multi-PAT project propofol

The NanoFlowSizer in combination with NIR spectroscopy was successfully applied to measure particle (droplet) size of a lipid nano-emulsion formulation with propofol (anesthetic for Covid-19 intensive care patients). For this formulation propofol (a hydrophobic liquid) is mixed with a commercially available lipid nano-emulsion, to encapsulate the propofol in the nano-droplets.

Measure propofol and droplet size

To evaluate whether the propofol uptake in the lipid nanodroplets was complete by applying different mixing procedures, droplet size was continuously measured as well as the content of propofol by NIR.

Results of the multi-PAT approach showed effective uptake of propofol for specific mixing procedures in real time.

Measure directly through glass

Due to the non-invasive character of both technologies and the ability to measure highly turbid suspensions all experiments were applied by measurements directly through the product glass bottle, which eliminated additional risks and effects related to sample handling and dilutions.

Read more in the Dutch article Farmaceutisch Weekblad.

Process Analytical Technology


There are multiple reasons to make use of PAT. One of the most common drivers for applying PAT is efficiency. For many processes …

PAT4nano Consortium


InProcess-LSP has a key position in consortium “PAT4nano”: a major new €5m project funded by the European Union’s Horizon 2020