Spectroscopy

Supporting your process with spectroscopy technologies

Blend uniformity

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NIR imaging – Powder

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Multi-PAT

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Near Infrared (NIR)

Thanks to major advantages related to the non-destructive character, ability to measure through glass, speed of analysis and versatility of equipment, NIR is widely used for for process analytical applications.

One of the most common challenges for NIR applications is quantitative calibration and interpretation of NIR spectra and data. InProcess-LSP works with spectroscopy hardware suppliers and offers extensive experience in NIR and chemometric modelling for at-line and on- or inline PAT solutions for solids and suspensions.

Combine NIR with NanoFlowSizer

InProcess-LSP can support you developing and implementing your application by making use of time-efficient and proven testing and calibration protocols.

Besides supporting PAT NIR application development, InProcess-LSP aims to combine spectroscopy solutions with the NanoFlowSizer technology in order to create ‘multi-PAT’ solutions to extend particle size data with additional information about composition, concentration and other relevant chemical or physical properties. 

Software for specific PAT solutions, commercially available software may not fulfill all requirements for effective operation and data interpretation. InProcess-LSP can work with you developing software and user interfaces for specific application areas. Starting point of InProcess-LSP is ‘non-exclusivity’ of developed software in order to keep development costs as low as possible for the customer.

Inline Blend Uniformity

Inline monitoring or control of powder blending processes provides major advantages in terms of process understanding, efficiency, cost saving and risk reduction in process development, tech transfer and manufacturing.

Proven strategy for high-quality approach

Applying an efficient and proven strategy for development and validation specifically for blend uniformity methods (either at InProcess-LSP or at customer site), InProcess-LSP assures a highly efficient and high-quality approach for you as a customer.

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NIR Imaging

Imaging analysis by NIR provides valuable information about spatially distributed ingredients. Uniformity of powder blends, tablets or other solid samples can be investigated by hyperspectral NIR images.

Valuable tool for understanding process

For either R&D or routine operation environment NIR imaging may be a valuable tool for either increased understanding of your process and product, or continuous quality control during production. NIR imaging involves beside processing of NIR spectra also (advanced) imaging analysis in order to extract the desired information from the images.

In the frontline of Process Analytical Technology

Multi-PAT

Combining spectroscopic methods like NIR with the NanoFlowSizer extends the range of information which can be extracted form the sample.

Besides particle size, additional information about concentration and compositions or other relevant properties may be obtained.

Since the NanoFlowSizer measures non-invasively through glass, combination with other non-invasive technologies like NIR will not jeopardize the non-invasive character of the measurements.

‘Multi-PAT’ is also a one of the focus areas of the EU funded PAT4Nano consortium in which InProcess-LSP is represented as well.

Multi-PAT project propofol

The NanoFlowSizer in combination with NIR spectroscopy was successfully applied to measure particle (droplet) size of a lipid nano-emulsion formulation with propofol (anesthetic for Covid-19 intensive care patients). For this formulation propofol (a hydrophobic liquid) is mixed with a commercially available lipid nano-emulsion, to encapsulate the propofol in the nano-droplets.

Measure propofol and droplet size

To evaluate whether the propofol uptake in the lipid nano droplets was complete by applying different mixing procedures, droplet size was continuously measured as well as the content of propofol by NIR.

Results of the multi-PAT approach showed effective uptake of propofol for specific mixing procedures in real time.

Measure directly through glass

Due to the non-invasive character of both technologies and the ability to measure highly turbid suspensions all experiments were applied by measurements directly through the product glass bottle, which eliminated additional risks and effects related to sample handling and dilutions.

Read more in Dutch article Farmaceutisch Weekblad.

Process Analytical Technology

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There are multiple reasons to make use of PAT. One of the most common drivers for applying PAT is efficiency. For many processes …

PAT4nano Consortium

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InProcess-LSP has key position in consortium “PAT4nano”: a major new €5m project funded by the European Union’s Horizon 2020